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Quick introduction into the practice, straightforward involvement of laboratory technicians, easy tech transfer, easy translation  

Clinical Institute of Medical Genetics, Slovenia

We have more control of the results and more interaction with clinicians who follow the patients

Vall d'Hebron Hospital - Spain

Fast, accurate, easy to use… we succeed in having good results!

Laboratory of Human Genetics – E.O. Ospedali Galliera – Italy

June 22nd, 2017 - July 24th, 2017 | Erlangen, Germany | 101. Jahrestagung der Deutschen Gesellschaft für Pathologie e.V. 2017 (DGP)

Guiding you towards better results. Every step of the way. 

Multiplicom has been a strong and reliable player in molecular diagnostics for many years. All our products and solutions incorporate the latest medical findings on human genetics, oncology and prenatal testing and are developed and manufactured in compliance with the most stringent international quality standards. 

Here at Multiplicom, we provide your laboratory with a broad range of molecular Next-Generation Sequencing (NGS) solutions, which guide your laboratory towards the most reliable results. Our ready-to-use kits analyze the genes that matter in a simple, efficient and reliable manner. Our Reporter software ensures correct analysis and enables quality control, from sample to final result. Our Facility lab and Expert customer support team help you to set up our tests and secure your results in every step of the way.

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OUR SOLUTIONS

Testkits & Reporters

News & Press

July 17th, 2017

Application note: CNV calling with MASTR Reporter

To guide you to optimal results for CNV analysis, we have written an application note. This note contains information on how to optimize your experiment and how the MASTR Reporter CNV calling algorithm works. Please note that because our MASTR Reporter now includes an optimized CNV calling algorithm, we will discontinue the CNV calculator for the BRCA MASTR, the BRCA HC MASTR Plus and the BRCA MASTR Plus assay from the 17th of August.

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June 15th, 2017

ESHG 2017: Post event

Multiplicom, now part of Agilent Technologies, was present at the 50th Anniversary of the European Human Genetics Conference (ESHG) 2017 from May 27 – 30 in Copenhagen, Denmark. During the ESHG, we successfully gave demos of our new MASTR Reporter software. This software ensures correct analysis and enables quality control from initial sample to result. It helps us to provide your laboratory with a broad range of Next-Generation Sequencing solutions, which can guide your laboratory towards reliable results.

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June 7th, 2017

Poster abstract EuroMedLab Athens 2017: Quantitative MPS analysis of BRCA1/2 genes. Novel CNeV algorithm for fast screening of large genomic rearrangements

Massively Parallel Sequencing (MPS) pipelines are widely used in molecular diagnostics providing both qualitative and quantitative information from target sequences. Several type of genomic variations could be detected by means of MPS analysis including single nucleotide variants (SNVs), small insertions or deletions (indels), copy number variations (CNVs) and large genomic rearrangements (LGRs).

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June 6th, 2017

Journal of Clinical Oncology: Accurate and precise targeted NGS with BRCA MASTR Plus Dx for BRCA1 and BRCA2 mutation detection in formalin-fixed paraffin-embedded tumor tissue-derived DNA.

Targeted next-generation sequencing (NGS) has tremendous potential in clinical diagnostics as it allows oncogenetic profiling to steer therapy. Inhibitors of poly-(ADP-ribose) polymerase (PARPi) have emerged as a new class of targeted anti-cancer drugs, specifically for tumors showing homologous recombination repair deficiency, including BRCA1- and BRCA2-mutated ovarian and breast cancers. This multicentre study evaluated the performance of BRCA MASTR Plus Dx*(Multiplicom) to routinely diagnose somatic and germline BRCA mutations in formalin-fixed paraffin-embedded (FFPE) tumor tissue-derived DNA.

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June 5th, 2017

Poster abstract EuroMedLab Athens 2017: High resolution melting analysis is very useful to identify BRCA1 c.4964_4982del19 (rs80359876) founder calabrian pathogenic variant on peripheral blood and buccal swab DNA

Different BRCA1 founder mutations are confined to geographically isolated regions or specific populations. BRCA1 5083del19 mutation is recurrent and specific to individuals of Italian descent with a founder effect on the Calabrian population. The correct identification of this type of mutation is one of pitfalls of NGS mainly due to insufficient coverage, read lenght or alignment quality.

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June 2nd, 2017

Journal of Clinical Oncology: Testing of BRCA 1/2 gene mutations in FFPE samples of patients with high-grade serous ovarian cancer and limits of its bioinformatic interpretation.

BRCA1/2 mutations represent first genetically defined predictive markers for targeted therapy of patients with recurrent high-grade serous carcinoma (HGSC), therefore patients with HGSC should be tested for a germline and somatic BRCA mutation (gBRCAm and sBRCAm, resp.). In our study we analyzed possibilities and limits for determination of both origin and pathogenicity of mutations detected by HGSC biopsies analyses.

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June 1st, 2017

Poster abstract EuroMedLab Athens 2017: Report of a fully automated massively parallel sequencing (MPS) library preparation for germline BRCA1/2 mutations testing by MONIA LH100 and LH75 (MASMEC) systems: experience of a reference laboratory

We perform about 1500 BRCA1/2 samples/year by MPS. In this context, library preparation for MPS is one of the most critical, on bench and time-consuming steps our pipeline. In addition, automation of library preparation phase is the best option to avoid the risk of human-introduced error. Our objective was to report a rapid, automated solution to prepare Multiplicom-NGS based protocol for Illumina MiSeq® sequencer for BRCA1/2 genes and to analyze the performance of MPS in terms of number of sequences/run, coverage uniformity and number of variants detected.

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May 30th, 2017

ESHG Poster Abstract: Integrated diagnostic solution for routine testing of mutations in BRCA1 and BRCA2 with the BRCA MASTR Plus Dx assay

Multiplicom’s BRCA MASTR Plus Dx is an CE-IVD assay for the identification or confirmation of the presence or absence of single nucleotide variants (SNVs) and small insertions and deletions (indels) in the complete coding regions of BRCA1 and BRCA2. CE-IVD was obtained when using BRCA MASTR Plus Dx in combination with the MID Dx kit for Illumina MiSeq on Formalin-Fixed, Paraffin-Embedded (FFPE)-derived DNA of patients with cancer. In tumors, mutations in BRCA1 and BRCA2 have prognostic value and predict response to molecular targeted therapy such as approved PARP inhibitors (PARPi).

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May 23rd, 2017

Journal of Cancer - Towards Prognostic Profiling of Non-Small Cell Lung Cancer: New Perspectives on the Relevance of Polo-Like Kinase 1 Expression, the TP53 Mutation Status and Hypoxia

Currently, prognosis of non-small cell lung cancer patients is based on clinicopathological factors, including TNM stage. However, there are considerable differences in patient outcome within a similar staging group, even when patients received identical treatments. In order to improve prognostic predictions and to guide treatment options, additional parameters influencing outcome are required.

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Events

June 22nd, 2017 - July 24th, 2017 | Erlangen, Germany

101. Jahrestagung der Deutschen Gesellschaft für Pathologie e.V. 2017 (DGP)

Come and visit our local representatives during the DGP meeting from 22 – 24 June 2017 in Erlangen, Germany. Check out our newest pathology solutions at our booth. The theme of this year’s meeting is Pathology: ‘innovation and cooperation’. 

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August 14th, 2017 - August 15th, 2017 | Belgian Offices

Bank Holiday 14 & 15 August 2017

Due to a Belgian Bank Holiday, our Belgian offices will be closed from 14 – 15 August 2017.The orders that we receive during week 32 (latest on Thursday 10th of August) from customers inside the European Union, will be shipped on Wednesday 16th of August. The other orders will be shipped in week 34.For more information or urgent requests on shipping, please contact orders@multiplicom.com.Our apologies for this inconvenience!

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September 2nd, 2017 - September 6th, 2017 | Amsterdam, The Netherlands

29th European Congress of Pathology (ECP-ESP)

From 2 – 6 September 2017, you can find Multiplicom at the 29th European Congress of Pathology in Amsterdam, The Netherlands. Visit us at our booth to find out more on the newest pathology solutions.

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September 12th, 2017 - September 15th, 2017 | Niel, Belgium

Full - Clarigo Workshop September

* This workshop is completely full. But don't worry, we have another workshop in October! * Multiplicom organizes workshops to help diagnostic centers implement Clarigo efficiently in their own laboratory facilities. The Clarigo workshop is intended to provide hands-on lab training of the complete Clarigo workflow and is therefore of particular interest to the person in charge of practical implementation or lab technicians.

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September 14th, 2017 - September 16th, 2017 | Wörthersee, Austria

Herbsttagung der Österreichischen Gesellschaft für Pathologie ÖGPath / Österreichische Abteilung der IAP

Multiplicom, now part of Agilent Technologies, is happy to welcome you during the Herbsttagung der Österreichischen Gesellschaft für Pathologie ÖGPath / Österreichische Abteilung der IAP from 14 – 16 September in Wörthersee, Austria. Discover our newest Next-Generation Sequencing solutions for Pathology or get a demo of our newest MASTR Reporter software.

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September 21st, 2017 - September 22nd, 2017 | Veldhoven, The Netherlands

NVHG Najaarssymposium 2017

Multiplicom, a part of Agilent Technologies, is proud Silver Sponsor of the NVHG Fall Symposium from 21 – 22 September 2017 in Veldhoven, The Netherlands. Come by our booth and meet our local representative. Discover our newest Next-Generation Sequencing solutions for Human Genetics.

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September 22nd, 2017 - September 24th, 2017 | Berlin, Germany

Deutsche Pathologietage Berlin 2017

Multiplicom, part of Agilent Technologies, is happy to welcome you in Berlin during the Deutsche Pathologietage from 22-24 September 2017. The congress, organized by the German Federal Association of Pathologists and the DVTA, recognizes the importance of continuous innovation in the field of pathology. Come by our booth no. 46 and get a demo of our newest innovation: the MASTR Reporter. Interested in finding out more on our Next-Generation Sequencing solutions? Make an appointment with our local representative!

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September 25th, 2017 - September 25th, 2017 | Nancy, France

Tumor Liquid Biopsy symposium

We are heading for France on 25 September 2017 for the Tumor Liquid Biopsy symposium in Nancy. Visit us at our booth and meet our local representatives. They will tell you all about our Next-generation sequencing solutions for diagnostics and screening

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September 27th, 2017 - September 29th, 2017 | Niel, Belgium

MASTR Workshop September

The MASTR workshop is intended to provide hands-on lab training of the complete MASTR and/or MASTR Plus workflow, and is therefore of particular interest to the person in charge of practical implementation or lab technicians.

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Frequently Asked Questions