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"Thanks to new Multiplicom test kits physicians are able to identify all the genetic mutations of a condition at once, and use this information to initiate the right - personalized - treatment.”

Somatic Mosaicism in Genodermatoses at BeSHG 2017

On February 17, 2017, we welcomed many people at our booth during the annual BeSHG meeting in Louvain-La-Neuve, Belgium. This year’s theme was ‘Human Genetics goes Somatic’. During our sponsored presentation, Hilde Brems from the Center of Human Genetics at KU Leuven talked about ‘Somatic Mosaicism in Genodermatoses’. She discussed how her laboratory combines two somatic assays, Tumor Hotspot MASTR™ Plus and SOMATIC 2 MASTR™ Plus, to help her lab provide solutions for Human genetic challenges.

The Tumor Hotspot MASTR™ Plus is a molecular assay (research use only) for the identification of variants in frequently mutated genes in solid tumors. This genetic panel of 26 frequently mutated genes (hotspots) focuses on actionable mutations in a wide variety of these solid tumors. This means they have either therapeutic or prognostic value, enabling a personalized medicine approach. Although the Tumor Hotspot MASTR™ Plus is mainly used for the molecular analysis of tumor samples, the Center of Human Genetics uses this panel to aid the diagnosis of patients with skin mosaicisms.

Furthermore, we presented a poster on Targeted Next-Generation Sequencing using BRCA MASTR™ Plus Dx. This is an accurate and precise diagnostic method for BRCA1 and BRCA2 mutation detection in formalin-fixed paraffin-embedded tissue-derived DNA. Next-Generation Sequencing (NGS) diagnostics for BRCA1 and BRCA2 have gained increasing interest due to the arrival of poly-(ADP-ribose) polymerase inhibitors (PARPi). PARPi are especially effective in the treatment of tumors that show homozygous mutations in BRCA1 and BRCA2. This assay can also be used on blood for germline mutation testing, making it a solution for all BRCA testing needs.

Interested in hearing more on our Multiplicom NGS solutions and how we can help you? Contact your local representative for more information!

BeSHG 2017

 

About the BeSHG

The BeSHG aims to create a forum where a wide scope of specialists including nurses, genetic counselors, clinical geneticists, molecular biologists and cytogeneticists involved in human genetics can interact and debate about their field of interest. For the last two years, more than 20 prestigious companies in the field, such as Multiplicom, sponsored the event.

For more information on the BeSHG, click here.